Undergraduate

Second Year MChem/BSc

Heteroaromatic Chemistry:

 

Learning Objectives:

Know the names and structures of the heteroaromatic rings presented.

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Understand the reactivity of these heteroaromatic rings and use this understanding to be able to functionalise and chemically transform these heteroaromatic ring systems.

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Disconnect heteroaromatic rings, using retrosynthetic analysis, into non-heteroaromatic precursors and hence propose syntheses of heteroaromatic ring compounds.

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Know the mechanisms of the reactions presented.

 

Course Outline:

Reactivity and synthesis of pyridines.

Reactivity and synthesis of pyrroles, thiophenes and furans.

Reactivity and synthesis of oxazoles, imidazoles and thiazoles.

Reactivity and synthesis of quinolines and isoquinolines.

Reactivity and synthesis of indoles.

Third Year MChem

 

Synthesis - Stereocontrolled Synthesis using Organomain Group Reagents

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Learning Objectives:

To appreciate the roles of organo-main group reagents containing B, Si and S in organic synthesis.

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To understand the mechanisms and reasons for the selectivities of the reagents and reactions discussed.

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To devise complex synthetic routes to target molecules using a range of new types of disconnections (e.g.: selective alkene formation, 1,2- and 1,3- stereochemistry, 1,2,3-stereochemical triads, chemoselectivity and regioselectivity using organo-main group reactions).

 

Course Outline:

Overview of organo-B, Si and S reactivity.

Stereocontrolled formation of functionalised alkenes.

Control of 1, 2-stereocentres in acyclic systems.

Control of 1, 2, 3-stereocentres in acyclic systems.

Control of 1, 3-stereocontres in acyclic systems.

Control of axial vs equatorial stereocentres in cyclohexane systems.

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Postgraduate

 

Practical Chromatography:

This class comprises of an introductory lecture and two afternoon laboratory sessions, where you will learn the 'tricks' of practical flash column and thin layer chromatography for synthetic organic chemistry projects.

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Course notes.

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Planning Synthetic Strategy and Retrosynthesis:

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This course comprises of an introductory lecture and a series of five workshops. The lecture will give a brief revision of undergraduate concepts before exploring more advanced retrosynthetic strategies. The workshops enable the consolidation of the material through problem solving and practice. 

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Course notes.

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